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Semaglutide dosing and estrous tracking Female mice were given an intraperitoneal injection of either semaglutide (n=80) at 0.01mg/kg or saline control (n=80)

The entry of -KG into the TCA cycle is highly regulated: Pyruvate Dehydrogenase Complex (PDC): The conversion of pyruvate to acetyl-CoA is tightly regulated by the PDC complex, which can be inhibited by acetyl-CoA (feedback inhibition) and activated by ADP